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January 06 2015

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Cerebrovascular adverse events (e.g. stroke, transient ischemic attack) which included fatalities have been reported in trials of olanzapine on elderly patients with dementia-related psychosis. There was a significantly higher incidence of cerebrovascular adverse events in patients treated with olanzapine when compared to patients treated with placebo. However, the association between the use of atypical antipsychotics (i.e. risperidone, olanzapine) and the risk of cerebrovascular events appears to be somewhat controversial. The results of a case-control study found no increased risk of cerebrovascular events in elderly patients treated with atypical antipsychotics.
The most serious adverse reactions experienced with clozapine are agranulocytosis, seizure, cardiovascular effects and fever.
No abnormal blood event (WBC at least 3500/mm3 and ANC at least 2000/mm3) and a break of greater than 3 days and less than or equal to 1 month duration - weekly for 6 weeks, then return to every 4 weeks.
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